Barcelona and Atlético Madrid will meet for a fifth time in European competition, with all five coming at the quarter-final stage of the UEFA Champions League (2013-14 and 2015-16 previously).

Atlético Madrid have only lost one of their previous four UEFA Champions League games against Barcelona (W2 D1), and have eliminated the Catalan side in both of their previous knockout stage ties (2-1 on aggregate in 2013-14 and 3-2 in 2015-16). Only Paris SG (3) have eliminated Barcelona more times in the knockout stages of the European Cup/Champions League.